LMPD Database

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LMP006491

UniProt Annotations

Entry Information
Gene NameDnaJ (Hsp40) homolog, subfamily A, member 1
Protein EntryDNJA1_HUMAN
UniProt IDP31689
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P31689-1; Sequence=Displayed; Name=2; Synonyms=nDnaJA1; IsoId=P31689-2; Sequence=VSP_046566;
FunctionCo-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co- chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202). {ECO
InductionUp-regulated by heat shock.
InteractionQ9GZX7:AICDA; NbExp=6; IntAct=EBI-347834, EBI-3834328;
SimilarityContains 1 CR-type zinc finger.
SimilarityContains 1 J domain.
Subcellular LocationMembrane ; Lipid-anchor . Cytoplasm {ECO
SubunitIdentified in a complex with HSPA1B and BAX.
Tissue SpecificityUbiquitous. Isoform 2 is highly expressed in testis and lung, but detected at low levels in thymus, prostate, colon and liver. {ECO