LMPD Database

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LMP006426

UniProt Annotations

Entry Information
Gene Nameestablishment of sister chromatid cohesion N-acetyltransferase 2
Protein EntryESCO2_HUMAN
UniProt IDQ56NI9
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q56NI9-1; Sequence=Displayed; Name=2; IsoId=Q56NI9-2; Sequence=VSP_055773, VSP_055774; Note=No experimental confirmation available.;
DiseaseRoberts syndrome (RBS) [MIM
DiseaseSC phocomelia syndrome (SCPS) [MIM
FunctionAcetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3. {ECO
SimilarityBelongs to the acetyltransferase family. ECO subfamily.
Subcellular LocationNucleus . Chromosome .
Tissue SpecificityWidely expressed in fetal tissues. In adult, it is expressed in thymus, placenta and small intestine.