LMPD Database

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LMP006424

UniProt Annotations

Entry Information
Gene NamePAK1 interacting protein 1
Protein EntryPK1IP_MOUSE
UniProt IDQ9DCE5
SpeciesMouse
Comments
Comment typeDescription
FunctionNegatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which have been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42 (By similarity). {ECO:0000250}.
SimilarityContains 5 WD repeats. {ECO:0000255|PROSITE- ProRule:PRU00221}.
Subcellular LocationNucleus, nucleolus {ECO:0000250}.
SubunitInteracts with PAK1. {ECO:0000250}.