LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP006399

UniProt Annotations

Entry Information
Gene Nameretinol saturase (all-trans-retinol 13,14-reductase)
Protein EntryRETST_HUMAN
UniProt IDQ6NUM9
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6NUM9-1; Sequence=Displayed; Name=2; IsoId=Q6NUM9-2; Sequence=VSP_017410, VSP_017411; Note=No experimental confirmation available.;
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6NUM9-1; Sequence=Displayed; Name=2; IsoId=Q6NUM9-2; Sequence=VSP_017410, VSP_017411; Note=No experimental confirmation available.;
Catalytic ActivityAll-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor.
CofactorName=NAD(+); Xref=ChEBI
CofactorName=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000250}; Name=NADP(+); Xref=ChEBI:CHEBI:58349; Evidence={ECO:0000250}; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
FunctionRetinol saturase carrying out the saturation of the 13- 14 double bond of all-trans-retinol to produce all-trans-13,14- dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A (By similarity).
FunctionRetinol saturase carrying out the saturation of the 13- 14 double bond of all-trans-retinol to produce all-trans-13,14- dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A (By similarity). {ECO:0000250}.
Sequence CautionSequence=AAH11418.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91069.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Sequence CautionSequence=AAH11418.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=BAA91069.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
SimilarityBelongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily.
SimilarityBelongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.