LMPD Database

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LMP006329

UniProt Annotations

Entry Information
Gene Namecholesterol 25-hydroxylase
Protein EntryCH25H_MOUSE
UniProt IDQ9Z0F5
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityCholesterol + AH(2) + O(2) = 25- hydroxycholesterol + A + H(2)O. {ECO:0000269|PubMed:9852097}.
CofactorName=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000269|PubMed:9852097};
Disruption PhenotypeMice do not display any apparent alteration in bile acid synthesis and cholesterol metabolism. {ECO:0000269|PubMed:12543708}.
FunctionCatalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation. {ECO:0000269|PubMed:9852097}.
PtmN-glycosylated. {ECO:0000269|PubMed:9852097}.
SimilarityBelongs to the sterol desaturase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:9852097}; Multi-pass membrane protein {ECO:0000269|PubMed:9852097}.
Tissue SpecificityWidely expressed at low level and at higher level in the lung. Weakly expressed in the heart, lung and kidney. {ECO:0000269|PubMed:9852097}.