LMPD Database

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LMP006313

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 27, subfamily b, polypeptide 1
Protein EntryCP27B_MOUSE
UniProt IDO35084
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityCalcidiol + NADPH + O(2) = calcitriol + NADP(+) + H(2)O.
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
FunctionCatalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D) to 1-alpha,25-dihydroxyvitamin D3 (1,25(OH)2D) plays an important role in normal bone growth, calcium metabolism, and tissue differentiation.
PathwayHormone biosynthesis; cholecalciferol biosynthesis.
Sequence CautionSequence=BAA22434.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular LocationMitochondrion membrane.
Tissue SpecificityKidney.