LMPD Database

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LMP006309

UniProt Annotations

Entry Information
Gene Namephospholipase D family, member 3
Protein EntryPLD3_MOUSE
UniProt IDO35405
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityA phosphatidylcholine + H(2)O = choline + a phosphatidate.
FunctionProbably involved in APP processing. {ECO:0000250}.
PtmGlycosylated. {ECO:0000250}.
SimilarityBelongs to the phospholipase D family. {ECO:0000305}.
SimilarityContains 2 PLD phosphodiesterase domains. {ECO:0000255|PROSITE-ProRule:PRU00153}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
SubunitInteracts with APP. {ECO:0000250}.
Tissue SpecificityExpressed at higher level in brain than in non-nervous tissue. Probably highly expressed in neurons. Expressed in mature neurons of the forebrain and appears to be turned on at late stages of neurogenesis. Expressed during late neuronal development in the forebrain. {ECO:0000269|PubMed:9813063}.