LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP006298

UniProt Annotations

Entry Information
Gene Nameretinol saturase (all trans retinol 13,14 reductase)
Protein EntryRETST_MOUSE
UniProt IDQ64FW2
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityAll-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor. {ECO:0000269|PubMed:15358783}.
CofactorName=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000250}; Name=NADP(+); Xref=ChEBI:CHEBI:58349; Evidence={ECO:0000250}; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
FunctionRetinol saturase carrying out the saturation of the 13- 14 double bond of all-trans-retinol to produce all-trans-13,14- dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A. {ECO:0000269|PubMed:15358783}.
InductionUp-regulated during starvation. {ECO:0000269|PubMed:18289917}.
Sequence CautionSequence=BAB22406.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:15358783}; Peripheral membrane protein {ECO:0000269|PubMed:15358783}.
Tissue SpecificityPredominantly expressed in the liver and kidney. Also expressed in intestine, white fat and brown fat. Weakly expressed in heart, skeletal muscle and testis and barely detected in the lung, brain and spleen. {ECO:0000269|PubMed:15358783, ECO:0000269|PubMed:18289917}.