LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP006200

UniProt Annotations

Entry Information
Gene Namephytanoyl-CoA hydroxylase interacting protein
Protein EntryB9EIC7_MOUSE
UniProt IDQ8K0S0
SpeciesMouse
Comments
Comment typeDescription
Developmental StageAt 18 dpc, expressed in most tissues, particularly in the skin. By neonatal day 1, the expression in brain and skin is markedly increased, whereas expression in the heart and skeletal muscles shows steady state levels similar to those observed in the fetus. At adulthood, very high expression in brain, little or no expression in other tissues. {ECO:0000269|PubMed:10686344}.
FunctionIts interaction with PHYH suggests a role in the development of the central system.
MiscellaneousOverexpression in heart induce atrial tachycardia and increased susceptibility to aconitine-induced arrhythmia, possibly due to altered expression of voltage-gated K(1+) channel and adrenergic beta1-receptor (ADRB1).
Sequence CautionSequence=AAH30494.2; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the PHYHIP family. {ECO:0000305}.
SimilarityContains 1 fibronectin type-III domain. {ECO:0000255|PROSITE-ProRule:PRU00316}.
SubunitInteracts with PHYH and BAI1. {ECO:0000269|PubMed:10686344, ECO:0000269|PubMed:11245925}.
Tissue SpecificityHighly expressed in the brain. {ECO:0000269|PubMed:10686344}.