LMPD Database

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LMP006194

UniProt Annotations

Entry Information
Gene Namecannabinoid receptor 2 (macrophage)
Protein EntryCNR2_MOUSE
UniProt IDP47936
SpeciesMouse
Comments
Comment typeDescription
Disruption PhenotypeMutant mice are responsive to the psychotropic effects of cannabinoid but not to the cannabinoid- induced immunomodulation. They also show accelerated age-related trabecular bone loss and cortical expansion. {ECO:0000269|PubMed:10822068}.
FunctionHeterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. {ECO:0000269|PubMed:10822068, ECO:0000269|PubMed:11929767, ECO:0000269|PubMed:16407142, ECO:0000269|PubMed:16563625, ECO:0000269|PubMed:16924491, ECO:0000269|PubMed:17401376, ECO:0000269|PubMed:18286196, ECO:0000269|PubMed:8679694}.
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Perikaryon {ECO:0000250}. Note=Localizes to apical dendrite of pyramidal neurons. {ECO:0000250}.
Tissue SpecificityExpressed by cells of hematopoietic origin. Expressed in skin in suprabasal layers and hair follicles, in brain by neurons and glial cells and by osteoblasts, osteocytes, osteoclasts (at protein level). {ECO:0000269|PubMed:11929767, ECO:0000269|PubMed:12511587, ECO:0000269|PubMed:16407142, ECO:0000269|PubMed:16924491, ECO:0000269|PubMed:18286196}.