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LMPD Database

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LMP006108

UniProt Annotations

Entry Information

Gene Name	mediator complex subunit 4
Protein Entry	MED4_MOUSE
UniProt ID	Q9CQA5
Species	Mouse

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9CQA5-1; Sequence=Displayed; Name=2; IsoId=Q9CQA5-2; Sequence=VSP_027918, VSP_027919; Note=No experimental confirmation available.;
Function	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). {ECO:0000250}.
Sequence Caution	Sequence=BAE26554.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity	Belongs to the Mediator complex subunit 4 family. {ECO:0000305}.
Subcellular Location	Nucleus {ECO:0000250}.
Subunit	Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity). {ECO:0000250}.