LMPD Database

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LMP006053

UniProt Annotations

Entry Information
Gene Namezinc finger, DHHC-type containing 9
Protein EntryZDHC9_HUMAN
UniProt IDQ9Y397
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityPalmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
DiseaseMental retardation, X-linked, syndromic, ZDHHC9-related (MRXSZ) [MIM
DomainThe DHHC domain is required for palmitoyltransferase activity.
FunctionThe ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.
Sequence CautionSequence=AAD34084.1; Type=Erroneous initiation; Evidence= ; Sequence=BAA91683.1; Type=Erroneous initiation; Evidence= ; Sequence=BAD93044.1; Type=Erroneous initiation; Evidence= ; Sequence=CAB82308.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
SimilarityContains 1 DHHC-type zinc finger.
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein .
SubunitInteracts with GOLGA7.
Tissue SpecificityHighly expressed in kidney, skeletal muscle, brain, lung and liver. Absent in thymus, spleen and leukocytes.