LMPD Database

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LMP006035

UniProt Annotations

Entry Information
Gene Nameestablishment of cohesion 1 homolog 1 (S. cerevisiae)
Protein EntryESCO1_MOUSE
UniProt IDQ69Z69
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q69Z69-1; Sequence=Displayed; Name=2; IsoId=Q69Z69-2; Sequence=VSP_014031, VSP_014032; Note=No experimental confirmation available.; Name=3; IsoId=Q69Z69-3; Sequence=VSP_014033, VSP_014034; Note=No experimental confirmation available.;
FunctionAcetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (By similarity). {ECO:0000250}.
Sequence CautionSequence=AAH08220.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC33830.1; Type=Frameshift; Positions=743; Evidence={ECO:0000305}; Sequence=BAD32575.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the acetyltransferase family. ECO subfamily. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Nuclear at interphase, associated with chromosomes during mitosis. {ECO:0000250}.