LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP006027

UniProt Annotations

Entry Information
Gene Nameinositol 1,3,4,5,6-pentakisphosphate 2-kinase
Protein EntryIPPK_MOUSE
UniProt IDQ6P1C1
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityATP + 1D-myo-inositol 1,3,4,5,6- pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate.
Developmental StageIn E9 embryos it is expressed in regions corresponding to the neural tube, notochord and somites. Through the neural tube, it is expressed in the ventricular zone and in migrating neuroblasts. Also expressed in the notochord and specific regions of the somite. Strongly expressed in the myotome (future skeletal muscle) of the somite. In addition to the neural tube, it is also expressed in the ventricular zone and migrating neuroblasts throughout the embryonic brain. Prominent expression is detected in the yolk sac and embryonic heart. Within the yolk sac, it is expressed in both the epithelial and endothelial layers (blood vessels) but absent from the blood islands. In the heart, it is detected in both the atrial and ventricular chambers. In the ventricular myocardium it is present in both the endocardium and myocardium. Also expressed in the cardinal vein, aorta, digestive tract, and pharyngeal arches.
Disruption PhenotypeDeath during ermbryogenesis before 8.5 dpc, suggesting that InsP6 is required for yolk sac function and development. {ECO:0000269|PubMed:15939868}.
DomainThe EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
FunctionPhosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. {ECO:0000269|PubMed:15939868}.
SimilarityBelongs to the IPK1 type 2 family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Tissue SpecificityIn brain, it is expressed throughout the hippocampus (CA1, CA2, CA3 and dentate gyrus), inner layers of the cerebral cortex, and Purkinje cells of the cerebellum. In heart, it is expressed in cardiomyocytes but not in interstitial cells, blood vessels, or valves. Also expressed in testis. {ECO:0000269|PubMed:15939868}.