LMPD Database

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LMP006023

UniProt Annotations

Entry Information
Gene NameRho GTPase activating protein 35
Protein EntryQ9NRY4_HUMAN
UniProt IDQ9NRY4
SpeciesHuman
Comments
Comment typeDescription
FunctionRepresses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'- GAGAAAAGAAACTGGAGAAACTC-3'. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor.
PtmPhosphorylation of Tyr-1105 by PTK6 promotes the association with RASA1, inactivating RHOA while activating RAS. Phosphorylation at Tyr-308 by PDGFRA inhibits binding to GTF2I. {ECO
Sequence CautionSequence=AAA58618.1; Type=Frameshift; Positions=389, 533, 540, 607, 614, 1167, 1241, 1292, 1334, 1446; Evidence= ; Sequence=AAF80386.1; Type=Frameshift; Positions=533, 540, 607, 614; Evidence= ; Sequence=AAF80386.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence= ;
SimilarityContains 1 Rho-GAP domain. {ECO
SimilarityContains 4 FF domains.
Subcellular LocationCytoplasm . Nucleus .
SubunitInteracts with RASA1. Interacts with the general transcription factor GTF2I, the interaction sequesters GTF2I in the cytoplasm.