LMPD Database

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LMP005986

UniProt Annotations

Entry Information
Gene NameUbiA prenyltransferase domain containing 1
Protein EntryUBIA1_MOUSE
UniProt IDQ9DC60
SpeciesMouse
Comments
Comment typeDescription
FunctionPrenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4- naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosyntetic enzyme: coenzyme Q10, also named ubiquinone, plays a important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress (By similarity). {ECO:0000250}.
PathwayCofactor biosynthesis; ubiquinone biosynthesis.
PathwayQuinol/quinone metabolism; menaquinone biosynthesis.
SimilarityBelongs to the UbiA prenyltransferase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Mitochondrion {ECO:0000250}.
SubunitInteracts with HMGCR and SOAT1. {ECO:0000250}.