LMPD Database

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LMP005942

UniProt Annotations

Entry Information
Gene Nameprotein geranylgeranyltransferase type I, beta subunit
Protein EntryPGTB1_MOUSE
UniProt IDQ8BUY9
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityGeranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250};
FunctionCatalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B (By similarity). {ECO:0000250}.
SimilarityBelongs to the protein prenyltransferase subunit beta family. {ECO:0000305}.
SimilarityContains 4 PFTB repeats. {ECO:0000305}.
SubunitHeterodimer of FNTA and PGGT1B. PGGT1B mediates interaction with substrate peptides (By similarity). {ECO:0000250}.