LMPD Database

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LMP005918

UniProt Annotations

Entry Information
Gene Namethioredoxin interacting protein
Protein EntryTXNIP_MOUSE
UniProt IDQ8BG60
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8BG60-1; Sequence=Displayed; Name=2; IsoId=Q8BG60-2; Sequence=VSP_020653;
Disruption PhenotypeMarked reduction in the numbers of natural killer cells, low levels of Il2rb expression in the precursor hematopoietic stem cells and severe lymphoid hyperplasia in the small intestine. {ECO:0000269|PubMed:15723808}.
FunctionMay act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. {ECO:0000250, ECO:0000269|PubMed:15723808, ECO:0000269|PubMed:15930262}.
PtmUbiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation. {ECO:0000250}.
SimilarityBelongs to the arrestin family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:10843682}.
SubunitHomodimer; disulfide-linked. Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4 (By similarity). {ECO:0000250}.
Tissue SpecificityUbiquitously expressed. {ECO:0000269|PubMed:10843682}.