LMPD Database

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LMP005840

UniProt Annotations

Entry Information
Gene NameN-acyl phosphatidylethanolamine phospholipase D
Protein EntryNAPEP_HUMAN
UniProt IDQ6IQ20
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityAn N-acylphosphatidylethanolamine + H(2)O = an N-acylethanolamine + a 1,2-diacylglycerol 3-phosphate.
CofactorName=Zn(2+); Xref=ChEBI
Enzyme RegulationActivity is stimulated by divalent cations.
FunctionHydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of anandamide (N- arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (By similarity).
SimilarityBelongs to the NAPE-PLD family.
Subcellular LocationMembrane .
SubunitMonomer.
Web ResourceName=Wikipedia; Note=N-acyl phosphatidylethanolamine-specific phospholipase D entry; URL="http://en.wikipedia.org/wiki/N-acyl_phosphatidylethanolamine-specific_phospholipase_D";