LMPD Database

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LMP005784

UniProt Annotations

Entry Information
Gene Namesynaptotagmin II
Protein EntrySYT2_MOUSE
UniProt IDP46097
SpeciesMouse
Comments
Comment typeDescription
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains. {ECO:0000250};
DomainThe first C2 domain mediates Ca(2+)-dependent phospholipid binding.
DomainThe second C2 domain mediates interaction with Stonin 2.
FunctionMay have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
InteractionQ8TAC9:SCAMP5 (xeno); NbExp=2; IntAct=EBI-457969, EBI-2695784; O35526:Stx1a; NbExp=2; IntAct=EBI-457969, EBI-400878;
SimilarityBelongs to the synaptotagmin family. {ECO:0000305}.
SimilarityContains 2 C2 domains. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Subcellular LocationCytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Note=Synaptic vesicles and chromaffin granules.
SubunitHomotetramer (Probable). Interacts with SCAMP5 (By similarity). Interacts with stonin 2. {ECO:0000250, ECO:0000305}.