LMPD Database

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LMP005782

UniProt Annotations

Entry Information
Gene NameG protein-coupled receptor 6
Protein EntryGPR6_HUMAN
UniProt IDP46095
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P46095-1; Sequence=Displayed; Name=2; IsoId=P46095-2; Sequence=VSP_055105;
CautionWas originally (PubMed:12220620) thought to be a receptor for sphingosine 1-phosphate. It has been demonstrated that it is not the case (PubMed:19286662). {ECO
FunctionOrphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity).
SimilarityBelongs to the G-protein coupled receptor 1 family.
Subcellular LocationCell membrane ; Multi-pass membrane protein . Note=Detected in the intracellular compartments. It is currently unclear whether this is a cell surface or intracellular receptor.