LMPD Database

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LMP005762

UniProt Annotations

Entry Information
Gene Namepyruvate dehydrogenase (lipoamide) beta
Protein EntryODPB_MOUSE
UniProt IDQ9D051
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityPyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2).
CofactorName=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000250};
FunctionThe pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000250}.
Sequence CautionSequence=AAH02188.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Subcellular LocationMitochondrion matrix {ECO:0000250}.
SubunitHeterotetramer of two PDHA1 and two PDHB subunits. The heterotetramer interacts with DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). These subunits are bound to an inner core composed of about 48 DLAT and 12 PDHX molecules (By similarity). {ECO:0000250}.