LMPD Database

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LMP005756

UniProt Annotations

Entry Information
Gene NameG protein-coupled receptor 68
Protein EntryOGR1_HUMAN
UniProt IDQ15743
SpeciesHuman
Comments
Comment typeDescription
CautionWas originally (PubMed:10806476) thought to be a receptor for sphingosylphosphorylcholine (SPC). However, this work has been retracted (PubMed:16508674). {ECO
FunctionProton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer (By similarity).
Sequence CautionSequence=AAH96071.1; Type=Erroneous initiation; Evidence= ; Sequence=AAH96072.1; Type=Erroneous initiation; Evidence= ; Sequence=AAH96073.1; Type=Erroneous initiation; Evidence= ; Sequence=AAH96074.1; Type=Erroneous initiation; Evidence= ; Sequence=AAH98567.1; Type=Erroneous initiation; Evidence= ; Sequence=AAT38917.1; Type=Erroneous initiation; Evidence= ; Sequence=ACG60649.1; Type=Erroneous initiation; Evidence= ; Sequence=EAW81447.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the G-protein coupled receptor 1 family.
Subcellular LocationCell membrane; Multi-pass membrane protein.
Tissue SpecificityFound at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/GPR68ID40745ch14q32.html";