LMPD Database

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LMP005729

UniProt Annotations

Entry Information
Gene Nameformyl peptide receptor 1
Protein EntryFPR1_MOUSE
UniProt IDP33766
SpeciesMouse
Comments
Comment typeDescription
FunctionHigh affinity receptor for N-formyl-methionyl peptides (FMLP), which are powerful neutrophils chemotactic factors. Stimulate chemotaxis in immune cells to site of infection or tissue damage upon recognition of several ligands, such as FMLP, or ligand involved in cell damage, disease or inflammation.
PtmPhosphorylated; which is necessary for desensitization. {ECO:0000250}.
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane; Multi-pass membrane protein.
Tissue SpecificityExpressed in neutrophils, dendritic cells, microglia, spleen, lung and liver. Low level of expression in the vomeronasal organ. {ECO:0000269|PubMed:19497865}.