LMPD Database

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LMP005719

UniProt Annotations

Entry Information
Gene Namephosphatase, orphan 1
Protein EntryPHOP1_MOUSE
UniProt IDQ8R2H9
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityO-phosphoethanolamine + H(2)O = ethanolamine + phosphate.
Catalytic ActivityPhosphocholine + H(2)O = choline + phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
FunctionPhosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization. {ECO:0000269|PubMed:17227223}.
SimilarityBelongs to the HAD-like hydrolase superfamily. PHOSPHO family. {ECO:0000305}.
Tissue SpecificityHas a 120-fold higher level of expression in bone compared with a range of soft tissues. {ECO:0000269|PubMed:17227223}.