LMPD Database

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LMP005686

UniProt Annotations

Entry Information
Gene Namenicotinamide riboside kinase 2
Protein EntryNRK2_MOUSE
UniProt IDQ9D7C9
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityATP + 1-(beta-D-ribofuranosyl)-nicotinamide = ADP + beta-nicotinamide D-ribonucleotide.
Catalytic ActivityATP + beta-D-ribosylnicotinate = ADP + nicotinate beta-D-ribonucleotide.
FunctionCatalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis (By similarity). {ECO:0000250}.
InductionDown-regulated during myoblast differentiation. {ECO:0000269|PubMed:10613898}.
PathwayCofactor biosynthesis; NAD(+) biosynthesis.
SimilarityBelongs to the uridine kinase family. NRK subfamily. {ECO:0000305}.
SubunitMonomer (By similarity). Interacts with ITGB1 alone or when associated with alpha-7, but not with alpha-5. {ECO:0000250}.
Tissue SpecificityExpressed in skeletal muscle (at protein level). {ECO:0000269|PubMed:10613898}.