LMPD Database

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LMP005682

UniProt Annotations

Entry Information
Gene Nameglycerophosphodiester phosphodiesterase domain containing 5
Protein EntryGDPD5_HUMAN
UniProt IDQ8WTR4
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8WTR4-1; Sequence=Displayed; Name=2; IsoId=Q8WTR4-2; Sequence=VSP_020816; Name=3; IsoId=Q8WTR4-3; Sequence=VSP_020815; Name=4; IsoId=Q8WTR4-4; Sequence=VSP_020814; Name=5; IsoId=Q8WTR4-5; Sequence=VSP_020813;
FunctionPromotes neurite formation. Cooperates with PRDX1 to drive postmitotic motor neuron differentiation. The glycerophosphodiester phosphodiesterase activity may be required for its role in neuronal differentiation. May contribute to the osmotic regulation of cellular glycerophosphocholine.
PtmIntramolecular disulfide bond between Cys-25 and Cys-571 is reduced by PRDX1.
Sequence CautionSequence=AAP97686.1; Type=Erroneous initiation; Evidence= ; Sequence=BAC11242.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the glycerophosphoryl diester phosphodiesterase family.
SimilarityContains 1 GP-PDE domain.
Subcellular LocationEndomembrane system ; Multi- pass membrane protein . Cytoplasm, perinuclear region {ECO
SubunitInteracts with PRDX1; forms a mixed-disulfide with PRDX1, leading to disrupt intramolecular disulfide bond between Cys-25 and Cys-571.