LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP005663

UniProt Annotations

Entry Information
Gene Namezinc finger, DHHC-type containing 2
Protein EntryZDHC2_HUMAN
UniProt IDQ9UIJ5
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityPalmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
DiseaseNote=Mutations in ZDHHC2 are found in hepatocellular carcinoma and colorectal cancer.
DomainThe DHHC domain is required for palmitoyltransferase activity.
FunctionPalmitoyltransferase specific for GAP43 and DLG4/PSD95.
SimilarityBelongs to the DHHC palmitoyltransferase family.
SimilarityContains 1 DHHC-type zinc finger.
Subcellular LocationMembrane ; Multi-pass membrane protein .
Tissue SpecificityUbiquitously expressed. Reduced expression in colorectal cancers with liver metastasis.