LMPD Database

LMP005653

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 4, subfamily a, polypeptide 14
Protein EntryO35728_MOUSE
UniProt IDO35728
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityOctane + 2 reduced rubredoxin + O(2) + 2 H(+) = 1-octanol + 2 oxidized rubredoxin + H(2)O.
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence= ;
FunctionCytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
InductionBy peroxisome proliferator methylclofenapate; 1000-fold in liver, 10-fold in kidney.
Sequence CautionSequence=BC089609; Type=Erroneous termination; Positions=365; Note=Translated as Gln.; Evidence= ;
SimilarityBelongs to the cytochrome P450 family.
Subcellular LocationEndoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue SpecificityVery low level in liver, kidney and spleen.