LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP005582

UniProt Annotations

Entry Information
Gene Namesphingosine-1-phosphate phosphotase 2
Protein EntrySGPP2_MOUSE
UniProt IDQ810K3
SpeciesMouse
Comments
Comment typeDescription
Developmental StageDevelopmentally regulated. Expression during kidney development increases around 8 fold from E11.5 and adult. Highest expression is found in the ureteric bud. {ECO:0000269|PubMed:19073640}.
FunctionHas specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling (By similarity). {ECO:0000250}.
SimilarityBelongs to the type 2 lipid phosphate phosphatase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.