LMPD Database

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LMP005534

UniProt Annotations

Entry Information
Gene Nameinositol polyphosphate-5-phosphatase F
Protein EntrySAC2_HUMAN
UniProt IDQ9Y2H2
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9Y2H2-1; Sequence=Displayed; Name=2; IsoId=Q9Y2H2-2; Sequence=VSP_033268, VSP_033269; Name=3; IsoId=Q9Y2H2-3; Sequence=VSP_033266, VSP_033267; Name=4; IsoId=Q9Y2H2-4; Sequence=VSP_046366, VSP_046367; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=14.3 uM for PtdIns(4,5)P2 (at pH 6.0) ;
FunctionInositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Hydrolyzes phosphatidylinositol 4,5- bisphosphate most effectively. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation.
MiscellaneousInositol polyphosphate 5-phosphatases usually have 2 conserved motifs that are essential for 5-phosphatase activity. However, INPP5F does not contain such motifs, and phosphatase activity seems to exist in the SAC domain, suggesting a new type of phosphoinositide 5-phosphatase.
Sequence CautionSequence=BAA76810.2; Type=Erroneous initiation; Evidence= ;
SimilarityContains 1 SAC domain. {ECO
Tissue SpecificityUbiquitous.