LMPD Database

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LMP005529

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 27, subfamily a, polypeptide 1
Protein EntryCP27A_MOUSE
UniProt IDQ9DBG1
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity5-beta-cholestane-3-alpha,7-alpha,12-alpha- triol + 3 NADPH + 3 O(2) = (25R)-3-alpha,7-alpha,12-alpha- trihydroxy-5-beta-cholestan-26-oate + 3 NADP(+) + 4 H(2)O.
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
FunctionCatalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta- cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3- 25-hydroxylase activity (By similarity). {ECO:0000250}.
PathwayHormone biosynthesis; cholecalciferol biosynthesis.
PtmAcetylation of Lys-125 and Lys-285 is observed in liver mitochondria from fasted mice but not from fed mice. {ECO:0000269|PubMed:23576753}.
SimilarityBelongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular LocationMitochondrion membrane {ECO:0000250}.