LMPD Database

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LMP005523

UniProt Annotations

Entry Information
Gene Nameestablishment of sister chromatid cohesion N-acetyltransferase 1
Protein EntryESCO1_HUMAN
UniProt IDQ5FWF5
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5FWF5-1; Sequence=Displayed; Name=2; IsoId=Q5FWF5-2; Sequence=VSP_014029, VSP_014030; Note=No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.;
CautionIt is uncertain whether Met-1 or Met-2 is the initiator.
DomainThe N-terminal region seems to be responsible for the association with chromosomes, thus excluding any involvement of the Zn finger in this process.
FunctionAcetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3. {ECO
PtmPhosphorylated during mitosis. {ECO
Sequence CautionSequence=AAH36943.1; Type=Miscellaneous discrepancy; Note=Wrong choice of frame.; Evidence= ; Sequence=BAB67804.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; Sequence=BAC03483.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
SimilarityBelongs to the acetyltransferase family. ECO subfamily.
Subcellular LocationNucleus. Chromosome. Note=Nuclear at interphase, associated with chromosomes during mitosis.
Tissue SpecificityWidely expressed. Expressed in heart, brain, liver, placenta, lung, kidney and pancreas. Highly expressed in muscle.