LMPD Database

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LMP005477

UniProt Annotations

Entry Information
Gene Nameglucuronidase, beta
Protein EntryP08236_HUMAN
UniProt IDP08236
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Long; IsoId=P08236-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P08236-2; Sequence=VSP_001799; Name=3; IsoId=P08236-3; Sequence=VSP_054830; Note=No experimental confirmation available.;
Catalytic ActivityA beta-D-glucuronoside + H(2)O = D-glucuronate + an alcohol.
DiseaseMucopolysaccharidosis 7 (MPS7) [MIM
DiseaseNote=Mucopolysaccharidosis type 7 is associated with non- immune hydrops fetalis, a generalized edema of the fetus with fluid accumulation in the body cavities due to non-immune causes. Non-immune hydrops fetalis is not a diagnosis in itself but a symptom, a feature of many genetic disorders, and the end-stage of a wide variety of disorders.
Enzyme RegulationInhibited by L-aspartic acid.
FunctionPlays an important role in the degradation of dermatan and keratan sulfates.
PtmN-linked glycosylated with 3 to 4 oligosaccharide chains. {ECO
SimilarityBelongs to the glycosyl hydrolase 2 family.
Subcellular LocationLysosome.
SubunitHomotetramer.