LMPD Database

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LMP005427

UniProt Annotations

Entry Information
Gene NameUDP-glucose glycoprotein glucosyltransferase 1
Protein EntryQ9NYU2_HUMAN
UniProt IDQ9NYU2
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NYU2-1; Sequence=Displayed; Name=2; IsoId=Q9NYU2-2; Sequence=VSP_036508;
CofactorName=Ca(2+); Xref=ChEBI
DomainThe N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects.
FunctionRecognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.
InductionBy tunicamycin and A23187. Induced 3-4 fold 10 hours after treatment.
PathwayProtein modification; protein glycosylation.
Sequence CautionSequence=AAY14885.1; Type=Erroneous gene model prediction; Evidence= ; Sequence=BAB14632.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the glycosyltransferase 8 family.
Subcellular LocationEndoplasmic reticulum lumen {ECO
SubunitMonomer as well as in a tight complex with SEP15 (By similarity). Interacts with METTL23. {ECO
Tissue SpecificityHigher levels in pancreas, skeletal muscle, kidney, and brain. Low levels in lung and heart.
Web ResourceName=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=UGGT1";