LMPD Database

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LMP005420

UniProt Annotations

Entry Information
Gene Namephosphoserine phosphatase
Protein EntrySERB_HUMAN
UniProt IDP78330
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityO-phospho-L(or D)-serine + H(2)O = L(or D)- serine + phosphate. {ECO
CofactorName=Mg(2+); Xref=ChEBI
DiseasePhosphoserine phosphatase deficiency (PSPHD) [MIM
Enzyme RegulationInhibited by calcium ions.
FunctionCatalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates.
InteractionQ9NVP2:ASF1B; NbExp=1; IntAct=EBI-1042956, EBI-1055650; Q14558:PRPSAP1; NbExp=1; IntAct=EBI-1042956, EBI-724449; Q9Y6J8:STYXL1; NbExp=1; IntAct=EBI-1042956, EBI-1044511;
PathwayAmino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.
SimilarityBelongs to the SerB family.
SubunitHomodimer. {ECO