LMPD Database

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LMP005417

UniProt Annotations

Entry Information
Gene Namephosphatidic acid phosphatase type 2 domain containing 1B
Protein EntryPPC1B_HUMAN
UniProt IDQ8NEB5
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8NEB5-1; Sequence=Displayed; Name=2; IsoId=Q8NEB5-2; Sequence=VSP_025241, VSP_025242; Name=3; IsoId=Q8NEB5-3; Sequence=VSP_040055; Name=4; IsoId=Q8NEB5-4; Sequence=VSP_054076, VSP_054077; Note=No experimental confirmation available. Gene prediction based on EST data.;
Biophysicochemical PropertiesKinetic parameters: KM=41 uM for diacylglycerol pyrophosphate ; KM=277 uM for phosphatidate ; KM=295 uM for lysophosphatidate ;
Catalytic ActivityA 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
Enzyme RegulationInhibited by N-ethylmaleimide.
FunctionDisplays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma. {ECO
Sequence CautionSequence=AAI06015.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=AAK14924.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
SimilarityBelongs to the PA-phosphatase related phosphoesterase family.
Subcellular LocationMembrane ; Multi-pass membrane protein .
Tissue SpecificityUbiquitous.