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LMPD Database

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LMP005403

UniProt Annotations

Entry Information

Gene Name	protein arginine N-methyltransferase 7
Protein Entry	ANM7_MOUSE
UniProt ID	Q922X9
Species	Mouse

Comments

Comment type	Description
Catalytic Activity	S-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine + N(omega)-methyl-arginine-[histone].
Catalytic Activity	S-adenosyl-L-methionine + [myelin basic protein]-arginine = S-adenosyl-L-homocysteine + [myelin basic protein]-N(omega)-methyl-arginine.
Developmental Stage	Present in undifferentiated embryonic stem and germ cells; expression is lost when cells differentiate. In the developing testis, it is expressed at all stages. Present in all cells within the developing tubule, including gonocytes and spermatogonia (at protein level). It the developing kidney, it is confined to the nephrogenic zone in the cortical region, where the tips of the ureteric bud induce de novo formation of epithelia in the metanephric mesenchyme and early glomeruli. Expression is around 8-fold lower in adult kidneys. {ECO:0000269\|PubMed:15699352, ECO:0000269\|PubMed:17048991, ECO:0000269\|PubMed:18449859}.
Function	Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo (By similarity). {ECO:0000250}.
Sequence Caution	Sequence=BAD32582.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity	Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N- methyltransferase family. PRMT7 subfamily. {ECO:0000255\|PROSITE- ProRule:PRU01015}.
Similarity	Contains 2 SAM-dependent MTase PRMT-type domains. {ECO:0000255\|PROSITE-ProRule:PRU01015}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}.
Subunit	Homodimer and heterodimer. Interacts with PRMT5 and SNRPD3 (By similarity). Interacts with CTCFL. {ECO:0000250, ECO:0000269\|PubMed:17048991}.