LMPD Database

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LMP005391

UniProt Annotations

Entry Information
Gene Nameproteolipid protein (myelin) 1
Protein EntryMYPR_MOUSE
UniProt IDP60202
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P60202-1; Sequence=Displayed; Name=DM-20; IsoId=P60202-2; Sequence=VSP_009194;
DiseaseNote=Defects in Plp1 are the cause of the dysmyelinating diseases Jimpy and Rumpshaker (rsh).
FunctionThis is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
SimilarityBelongs to the myelin proteolipid protein family. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:17634366}; Multi-pass membrane protein {ECO:0000269|PubMed:17634366}. Myelin membrane {ECO:0000269|PubMed:17634366}. Note=Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat.