LMPD Database

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LMP005370

UniProt Annotations

Entry Information
Gene Nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
Protein Entry1433F_MOUSE
UniProt IDP68510
SpeciesMouse
Comments
Comment typeDescription
FunctionAdapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). {ECO:0000250}.
InteractionQ5S006:Lrrk2; NbExp=4; IntAct=EBI-444641, EBI-2693710; Q9WVS6:Park2; NbExp=8; IntAct=EBI-444641, EBI-973635; O55042:Snca; NbExp=2; IntAct=EBI-444641, EBI-2310271; P21580:TNFAIP3 (xeno); NbExp=3; IntAct=EBI-444641, EBI-527670;
PtmPhosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion. {ECO:0000269|PubMed:9705322}.
SimilarityBelongs to the 14-3-3 family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer (By similarity). Interacts with many nuclear hormone receptors and cofactors including AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Weakly interacts with CDKN1B (By similarity). Interacts with ARHGEF28 and CDK16. Interacts with KCNK18 in a phosphorylation-dependent manner. Interacts with SAMSN1. Interacts with the 'Ser-241' phosphorylated form of PDPK1 (By similarity). {ECO:0000250}.