LMPD Database

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LMP005343

UniProt Annotations

Entry Information
Gene Namering finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
Protein EntryZN363_HUMAN
UniProt IDQ96PM5
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=8; Name=1; Synonyms=A; IsoId=Q96PM5-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q96PM5-2; Sequence=VSP_038467; Name=3; Synonyms=C; IsoId=Q96PM5-3; Sequence=VSP_038468; Name=4; Synonyms=Pirh2b; IsoId=Q96PM5-4; Sequence=VSP_044085; Note=No ubiquitin protein ligase activity. Down-regulated in hepatocellular carcinoma.; Name=5; Synonyms=Pirh2D; IsoId=Q96PM5-5; Sequence=VSP_053385, VSP_053386; Name=6; IsoId=Q96PM5-6; Sequence=VSP_053787; Note=No experimental confirmation available. Gene prediction based on EST data.; Name=7; IsoId=Q96PM5-7; Sequence=VSP_053788; Note=No experimental confirmation available. Gene prediction based on partial mRNA data.; Name=8; IsoId=Q96PM5-8; Sequence=VSP_053788, VSP_038467; Note=No experimental confirmation available. Gene prediction based on EST data.;
FunctionMediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity. {ECO
InductionUp-regulated during the S phase of the cell cycle. Expressed at low levels during G phase.
InteractionQ9NVV5:AIG1; NbExp=4; IntAct=EBI-947779, EBI-3942989; P18085:ARF4; NbExp=3; IntAct=EBI-947779, EBI-1237085; Q6UXH0:C19orf80; NbExp=2; IntAct=EBI-947779, EBI-3943039; P62158:CALM3; NbExp=2; IntAct=EBI-947779, EBI-397435; P04196:HRG; NbExp=3; IntAct=EBI-947779, EBI-3915012; Q969F2:NKD2; NbExp=2; IntAct=EBI-947779, EBI-1538629; Q9UBE8:NLK; NbExp=5; IntAct=EBI-947779, EBI-366978; P04637:TP53; NbExp=7; IntAct=EBI-947779, EBI-366083;
PathwayProtein modification; protein ubiquitination.
PtmSubject to ubiquitination and proteasomal degradation. Interaction with PLAGL2 or KAT5 enhances protein stability.
Sequence CautionSequence=BAD92309.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ;
SimilarityContains 1 CHY-type zinc finger. {ECO
SimilarityContains 1 CTCHY-type zinc finger.
SimilarityContains 1 RING-type zinc finger.
Subcellular LocationNucleus. Nucleus speckle. Cytoplasm.
SubunitMonomer and homodimer. Interacts with AR, p53/TP53, MDM2, HDAC1, KAT5, PLAG1, PLAGL2, CDKN1B, COPE, UBE2D2 and GORAB/NTKLBP1. {ECO
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/RCHY1ID43012ch04q21.html";