LMPD Database

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LMP005318

UniProt Annotations

Entry Information
Gene Namehydroxysteroid (17-beta) dehydrogenase 6
Protein EntryH17B6_MOUSE
UniProt IDQ9R092
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
Catalytic ActivityAll-trans-retinol-[cellular-retinol-binding- protein] + NAD(+) = all-trans-retinal-[cellular-retinol-binding- protein] + NADH.
Catalytic ActivityTestosterone + NAD(+) = androstenedione + NADH.
FunctionNAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). {ECO:0000269|PubMed:10537158}.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular LocationMicrosome membrane {ECO:0000269|PubMed:10537158}; Peripheral membrane protein {ECO:0000269|PubMed:10537158}; Lumenal side {ECO:0000269|PubMed:10537158}. Early endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Lumenal side {ECO:0000305}.
Tissue SpecificityDetected in liver. {ECO:0000269|PubMed:10537158}.