LMPD Database

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LMP005209

UniProt Annotations

Entry Information
Gene Namephosphoinositide-3-kinase, regulatory subunit 4
Protein EntryPI3R4_HUMAN
UniProt IDQ99570
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + a protein = ADP + a phosphoprotein.
CofactorName=Mn(2+); Xref=ChEBI
FunctionRegulatory subunit of the PI3K complex. May regulate membrane trafficking late in the endocytic pathway.
PtmMyristoylated.
PtmProbably autophosphorylated. {ECO
SimilarityBelongs to the protein kinase superfamily. Ser/Thr protein kinase family.
SimilarityContains 1 protein kinase domain.
SimilarityContains 3 HEAT repeats. {ECO
SimilarityContains 7 WD repeats. {ECO
Subcellular LocationLate endosome . Note=Localizes also to discrete punctae along the ciliary axoneme.
SubunitHeterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with the phosphatidylinositol 3-kinase type 3 (PIK3C3). Forms a complex with BECN1, PIK3C3 and either UVRAG and KIAA0226/Rubicon, or with ATG14. In this complex, presence of UVRAG and ATG14 are mutually exclusive. Part of a complex composed by PIK3C3 and PIK3CB (By similarity). Interacts with RAB7A in the presence of PIK3C3/VPS34. {ECO
Tissue SpecificityUbiquitously expressed.