LMPD Database

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LMP005157

UniProt Annotations

Entry Information
Gene Nameglucosaminyl (N-acetyl) transferase 3, mucin type
Protein EntryGCNT3_MOUSE
UniProt IDQ5JCT0
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityUDP-N-acetyl-D-glucosamine + beta-D- galactosyl-1,3-N-acetyl-D-galactosaminyl-R = UDP + beta-D- galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D- galactosaminyl-R.
Catalytic ActivityUDP-N-acetyl-D-glucosamine + beta-D- galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D- glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R.
FunctionGlycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development (By similarity). {ECO:0000250}.
PathwayProtein modification; protein glycosylation.
PtmN-glycosylated. {ECO:0000250}.
Sequence CautionSequence=AAH18297.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB25548.1; Type=Erroneous termination; Positions=35; Note=Translated as Cys.; Evidence={ECO:0000305};
SimilarityBelongs to the glycosyltransferase 14 family. {ECO:0000305}.
Subcellular LocationGolgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Web ResourceName=Functional Glycomics Gateway - GTase; Note=core 2 beta 6 GlcNAc T3; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_575";