LMPD Database

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LMP005150

UniProt Annotations

Entry Information
Gene Namelipolysis stimulated lipoprotein receptor
Protein EntryLSR_MOUSE
UniProt IDQ99KG5
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q99KG5-1; Sequence=Displayed; Name=2; IsoId=Q99KG5-2; Sequence=VSP_019696; Name=3; IsoId=Q99KG5-3; Sequence=VSP_019695;
Developmental StageExpressed during embryogenesis (at protein level). Detected from E7.5 to E17. {ECO:0000269|PubMed:15265030}.
Disruption PhenotypeDeath between E12.5 and E15.5 probably due to impaired liver and embryonic development. {ECO:0000269|PubMed:15265030}.
FunctionProbable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). {ECO:0000250}.
Sequence CautionSequence=AAA92719.1; Type=Frameshift; Positions=2; Evidence={ECO:0000305};
SimilarityBelongs to the immunoglobulin superfamily. LISCH7 family. {ECO:0000305}.
SimilarityContains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
SubunitHomotrimer or homotetramer. {ECO:0000250}.
Tissue SpecificitySpecifically expressed in liver and to a lower extent in kidney (at protein level). Also detected in brain, testis, ovaries, adrenal gland, intestine, muscle, and lung. {ECO:0000269|PubMed:15265030}.