LMPD Database

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LMP005071

UniProt Annotations

Entry Information
Gene Namecollagen, type IV, alpha 3 (Goodpasture antigen) binding protein
Protein EntryC43BP_HUMAN
UniProt IDQ9Y5P4
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; Synonyms=CERTL; IsoId=Q9Y5P4-1; Sequence=Displayed; Name=2; Synonyms=Delta26, GPBPD26; IsoId=Q9Y5P4-2; Sequence=VSP_006276; Name=3; IsoId=Q9Y5P4-3; Sequence=VSP_041022;
CautionWas originally reported to have a protein kinase activity and to phosphorylate on Ser and Thr residues the Goodpasture autoantigen (in vitro).
DomainThe FFAT motif is required for interaction with VAPA and VAPB.
DomainThe PH domain targets the Golgi apparatus.
DomainThe START domain recognizes ceramides and diacylglycerol lipids, interacts with membranes, and mediates the intermembrane transfer of ceramides and diacylglycerol lipids.
FunctionShelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. {ECO
PtmPhosphorylation on Ser-132 decreases the affinity toward phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity. Inactivated by hyperphosphorylation of serine residues by CSNK1G2/CK1 that triggers dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. {ECO
SimilarityContains 1 PH domain. {ECO
SimilarityContains 1 START domain. {ECO
Subcellular LocationCytoplasm. Golgi apparatus. Endoplasmic reticulum. Note=Preferentially localized to the Golgi apparatus.
SubunitInteracts with COL4A3. Interacts with VAPA and VAPB. Interaction with VAPB is less efficient than with VAPA.
Tissue SpecificityWidely expressed.