LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP005046

UniProt Annotations

Entry Information
Gene NameST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
Protein EntrySIA7C_HUMAN
UniProt IDQ8NDV1
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8NDV1-1; Sequence=Displayed; Name=2; IsoId=Q8NDV1-2; Sequence=VSP_013218, VSP_013219;
Catalytic ActivityCMP-N-acetylneuraminate + alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1,3-(N-acetyl-D- galactosaminyl)-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3- beta-D-galactosyl-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D- galactosaminyl)-glycoprotein.
FunctionInvolved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity).
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase 29 family.
Subcellular LocationGolgi apparatus membrane ; Single-pass type II membrane protein .
Web ResourceName=Functional Glycomics Gateway - GTase; Note=ST6GalNAc III; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_632";
Web ResourceName=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST6GALNAC3";