LMPD Database

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LMP005028

UniProt Annotations

Entry Information
Gene Namephosphoinositide-3-kinase, regulatory subunit 6
Protein EntryPI3R6_MOUSE
UniProt IDQ3U6Q4
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3U6Q4-1; Sequence=Displayed; Name=2; IsoId=Q3U6Q4-2; Sequence=VSP_018257; Name=3; IsoId=Q3U6Q4-3; Sequence=VSP_018255, VSP_018256; Note=No experimental confirmation available.;
FunctionRegulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G proteins than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS. {ECO:0000269|PubMed:15797027, ECO:0000269|PubMed:16476736, ECO:0000269|PubMed:19906996}.
Subcellular LocationCytoplasm. Membrane; Peripheral membrane protein.
SubunitHeterodimer of a catalytic subunit (PIK3CG) and a regulatory (PIK3R6) subunit. The binding of PIK3R6 to PIK3CG may exclude the binding of PIK3R5 to PIK3CG. Interacts with beta-gamma G protein dimers. Interacts with PDE3B; the interaction allows recruitment of the PI3K gamma complex to a PDE3B:RAPGEF3 complex. {ECO:0000269|PubMed:15797027, ECO:0000269|PubMed:16476736}.
Tissue SpecificityHighly expressed in heart. In a lower extent, also expressed in brain, spleen, lung, liver, kidney, prostate, thyroid, salivary gland, dendritic cells, macrophages and neutrophils. {ECO:0000269|PubMed:16476736}.