LMPD Database

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LMP005021

UniProt Annotations

Entry Information
Gene Namezinc finger, DHHC-type containing 3
Protein EntryZDHC3_HUMAN
UniProt IDQ9NYG2
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NYG2-1; Sequence=Displayed; Name=2; IsoId=Q9NYG2-2; Sequence=VSP_006934;
Catalytic ActivityPalmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
DomainThe DHHC domain is required for palmitoyltransferase activity.
FunctionPalmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability. Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi (By similarity).
PtmAutopalmitoylated.
SimilarityBelongs to the DHHC palmitoyltransferase family.
SimilarityContains 1 DHHC-type zinc finger.
Subcellular LocationGolgi apparatus membrane ; Multi-pass membrane protein .