LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP005013

UniProt Annotations

Entry Information
Gene Namesolute carrier family 22 (organic cation transporter), member 4
Protein EntryS22A4_MOUSE
UniProt IDQ9Z306
SpeciesMouse
Comments
Comment typeDescription
CautionIt is unclear whether it transports carnitine in vivo. {ECO:0000305}.
FunctionSodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. {ECO:0000269|PubMed:11010964}.
SimilarityBelongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000269|PubMed:11010964}; Multi-pass membrane protein {ECO:0000269|PubMed:11010964}.
SubunitInteracts with PDZK1. {ECO:0000269|PubMed:14531806}.
Tissue SpecificityExpressed in kidney, liver and testis. Weakly expressed in other tissues. {ECO:0000269|PubMed:11010964}.